W1: Discussion 2

Part 1: Discuss Morphology of cells and the factor it plays in general function and structure.

Part 2: Complete Case Study:
A 2 two year old  male presents with a retinal tumor and ultimately Retinoblastoma.

1. What is retinoblastoma, and what is the pattern of inheritance for this type of cancer?
2. What type of gene is the retinoblastoma gene, and how does mutation in this gene give rise to cancer? Be sure to indicate the consequences of mutating one or both of the alleles for this gene.
3. What is the difference between a germline and a somatic mutation?
4. What is the normal function of the pRB protein with regard to cell cycle regulation?

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