Vancomycin therapy for Methicillin Resistant Staphylococcus Aureus

This assignment will allow you to further your investigation of a pathophysiological (disease) process and the pharmacological treatment of this process. You will communicate the scientific and clinical information about these aspects of disease in a short written report of no more than 600 words.

As with Assignment 1, this task is intended to familiarise you with the key pharmacological and therapeutic aspects of using drugs to treat common pathophysiological conditions. You will investigate the use of a drug compound commonly used in the treatment of one of the following pathophysiological conditions;

Bacterial infection, cancer, hypertension, osteoarthritis, rheumatoid arthritis or asthma.

You will find a drug compound (its non-proprietary name must be used) used to treat the disease of your choice, and provide a short outline of the following criteria based on research literature sources, such as journal articles, medical and scientific text books, or scientific web based resources (e.g. NIH website, American Heart Association website).

1. Descriptive title, approximately 10 words, informing the reader of the condition and the drug used to treat it including the drug class and action;
2. Detailed but concise description of the key pathophysiological features of the disorder, including specific alterations from normal anatomy and physiology to the pathophysiological state and an explanation of any risk factors and complications associated with the disease;
3. Introduce the drug used to treat your chosen disease and describe the pharmacodynamics of the drug. This should be a detailed description of one pharmacological agent used to treat or prevent the disease, including the mechanism by which the drug treats/prevents the disease;
4. Describe the known side-effects and contra-indications.

You will also be required to submit a short written reflection on how the feedback from Assignment 1 was used to help you in the preparation for Assignment 2. The reflection should be approximately 100 words, but no more than 1 A4 page. The reflection should be attached at the beginning of Assignment 2.
Writing format.
This exercise is designed to develop your ability to identify and communicate scientific and clinical details in a concise written format, using appropriate referencing. The word limit is a maximum and marks will be deducted for exceeding the word limit. The assignment should be written in a fluent and economical sentence structure using subheadings where appropriate, and include correctly formatted in-text referencing according to APA referencing style. An APA referencing guide is available through the subject’s interact site and in-text and reference list formats must rigidly adhere to this style. (Marks will be deducted for incorrect formatting).

The reference list (correctly formatted) should follow the main section and would not be expected to contain more than 5 references including at least one recent journal article relevant to the topic. Dot-point format is unacceptable and will result in mark deduction. Files must be submitted via EASTS in .doc, .docx or pdf format, and include a word count below the references list. The word count does not include the reference list, but does include titles and headings.
Rationale
This assignment builds on the foundation of Assignment 1 to further develop your understanding of the pathophysiology and pharmacology of your chosen condition, focussing specifically on the pharmacodynamics of your chosen drug. The aim is to develop a model whereby you describe pathophysiological changes to normal anatomy and physiology and identify the targets for pharmacological intervention, and therefore the rationale for using them. A feature of this assessment task is the requirement to use your feedback from Assignment 1 to help you prepare Assignment 2. This requires you to reflect on the feedback provided and use it to improve your submission. This assessment task also provides an opportunity for you to develop your academic writing skills and receive feedback to assist you in your exam preparation.

This assessment item assesses the following learning outcomes (p.3):
* define common pathophysiological and pharmacological terms;
* describe characteristics and origin of different types of cellular injury;
* demonstrate an understanding of cellular adaptation to injury;
* identify the interaction and relative contribution genetic and environmental factors have on health breakdown;
* outline key pharmacodynamic principles (eg agonist and antagonists, receptor-drug interactions);

And depending on your choice of condition, the assignment will also assess:
* describe the characteristics of cancerous cells;
* describe the involvement of microorganisms in disease;
* name and describe the actions of the major classes of antimicrobial drugs;
* outline the major haematological pathologies and malignancies;
* describe the pathogenesis of major cardiovascular system dysfunction;
* outline the primary pharmacological interventions used in the treatment of cardiovascular disease;
* describe the pathogenesis of common respiratory dysfunctions;
* describe use of pharmacological agents in the treatment and management of respiratory pathophysiological states;
* describe the major types of musculoskeletal pathology including both mechanical and physiological injuries;
* demonstrate understanding of the origin and main theories of pain; and
* explain the pharmacological treatment of inflammation and pain.

 

 

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